Avène Cleanance Comedomed Anti-Blemish Concentrate by Pierre Fabre is a targeted anti-blemish concentrate formulated with Comedomed® technology to reduce comedones, prevent new blemish formation, and improve skin clarity. Designed for patients with comedonal and mild inflammatory acne requiring a gentle, effective daily treatment.

Indications: Comedonal acne (blackheads and whiteheads) requiring targeted treatment. Mild inflammatory acne with papules and pustules. Acne-prone skin requiring daily preventive blemish treatment. Sensitive acne-prone skin requiring a gentle, non-irritating treatment. Patients seeking a retinol-free alternative for comedone reduction.

Key Ingredients: Comedomed® (Retinaldehyde + Linoleic Acid) — Avène's proprietary anti-comedone complex that normalises follicular keratinisation, reduces comedone formation, and regulates sebum composition without the irritation of conventional retinoids. Avène Thermal Spring Water — naturally soothing, anti-irritant thermal water that calms reactive skin and reduces inflammation. Zinc Gluconate — sebum-regulating and antimicrobial agent that reduces excess oil and controls acne-causing bacteria. Diolenyl® — patented sebum-regulating complex that normalises sebaceous gland activity.

How to Use: Apply to clean, dry face morning and/or evening after cleansing. Dispense a small amount and apply to entire face or blemish-prone areas. Gently massage until fully absorbed. Follow with moisturiser and SPF 30+ in the morning. Allow 8–12 weeks for full therapeutic benefit.

Precautions: For external use only. Avoid contact with eyes — rinse immediately if contact occurs. Discontinue if irritation or allergic reaction develops. Keep out of reach of children. Store in a cool, dry place below 25°C. Manufactured by Pierre Fabre Dermo-Cosmétique, France. Available exclusively at NDMEDS.